Products

Western Blot (Cell lysate)

PSMC6 monoclonal antibody (M02), clone 2C4. Western Blot analysis of PSMC6 expression in NIH/3T3(Cat # L018V1 ).

Western Blot (Cell lysate)

PSMC6 monoclonal antibody (M02), clone 2C4 Western Blot analysis of PSMC6 expression in Hela S3 NE ( Cat # L013V3 ).

Western Blot (Cell lysate)

PSMC6 monoclonal antibody (M02), clone 2C4. Western Blot analysis of PSMC6 expression in PC-12(Cat # L012V1 ).

Western Blot (Transfected lysate)

Western Blot analysis of PSMC6 expression in transfected 293T cell line by PSMC6 monoclonal antibody (M02), clone 2C4.

Lane 1: PSMC6 transfected lysate(44.2 KDa).
Lane 2: Non-transfected lysate.

Western Blot (Recombinant protein)

ELISA

RNAi Knockdown (Antibody validated)

Western blot analysis of PSMC6 over-expressed 293 cell line, cotransfected with PSMC6 Validated Chimera RNAi ( Cat # H00005706-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with PSMC6 monoclonal antibody (M02), clone 2C4 (Cat # H00005706-M02 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.

Immunofluorescence

Immunofluorescence of monoclonal antibody to PSMC6 on HeLa cell. [antibody concentration 10 ug/ml]

Entrez GeneID

5706

GeneBank Accession#

BC005390

Protein Accession#

AAH05390

Gene Name

PSMC6

Gene Alias

CADP44, MGC12520, P44, SUG2, p42

Gene Description

proteasome (prosome, macropain) 26S subunit, ATPase, 6

Omim ID

602708

Gene Ontology

Hyperlink

Gene Summary

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq

Other Designations

26S protease regulatory subunit S10B|conserved ATPase domain protein 44|proteasome 26S ATPase subunit 6|proteasome subunit p42