PSMC2 monoclonal antibody (M01), clone 4C10-2C8
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More Files
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Western Blot (Cell lysate)
PSMC2 monoclonal antibody (M01), clone 4C10-2C8 Western Blot analysis of PSMC2 expression in SW-13 ( Cat # L005V1 ).
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PSMC2 is 0.3 ng/ml as a capture antibody.
Immunofluorescence
Immunofluorescence of monoclonal antibody to PSMC2 on HeLa cell. [antibody concentration 10 ug/ml]
Western Blot detection against Immunogen (73.37 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant PSMC2.
Immunogen
PSMC2 (AAH02589.1, 1 a.a. ~ 433 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN
Host
Mouse
Reactivity
Human
Isotype
IgG1 kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (73.37 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
PSMC2 monoclonal antibody (M01), clone 4C10-2C8 Western Blot analysis of PSMC2 expression in SW-13 ( Cat # L005V1 ).Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PSMC2 is 0.3 ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to PSMC2 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — PSMC2
Entrez GeneID
5701GeneBank Accession#
BC002589Protein Accession#
AAH02589.1Gene Name
PSMC2
Gene Alias
MGC3004, MSS1, Nbla10058, S7
Gene Description
proteasome (prosome, macropain) 26S subunit, ATPase, 2
Omim ID
154365Gene Ontology
HyperlinkGene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. [provided by RefSeq
Other Designations
mammalian suppressor of sgv-1 of yeast|protease 26S subunit 7|proteasome 26S ATPase subunit 2|proteasome 26S subunit, ATPase, 2|putative protein product of Nbla10058
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Interactome
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Pathway
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