Products

Western Blot (Transfected lysate)

Immunofluorescence

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

PSMB7

Gene Alias

Z

Gene Description

proteasome (prosome, macropain) subunit, beta type, 7

Omim ID

Gene Ontology

Gene Summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit). [provided by RefSeq

Other Designations

OTTHUMP00000022798|macropain chain Z|multicatalytic endopeptidase complex chain Z|proteasome beta 7 subunit|proteasome catalytic subunit 2|proteasome subunit Z|proteasome subunit alpha|proteasome subunit beta 7