PSMB5 purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human PSMB5 protein.
Immunogen
PSMB5 (NP_002788.1, 1 a.a. ~ 263 a.a) full-length human protein.
Sequence
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
Host
Rabbit
Reactivity
Human, Mouse
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
PSMB5 MaxPab rabbit polyclonal antibody. Western Blot analysis of PSMB5 expression in mouse spleen.Western Blot (Transfected lysate)
Western Blot analysis of PSMB5 expression in transfected 293T cell line (H00005693-T04) by PSMB5 MaxPab polyclonal antibody.
Lane 1: PSMB5 transfected lysate(28.50 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — PSMB5
Entrez GeneID
5693GeneBank Accession#
NM_002797.2Protein Accession#
NP_002788.1Gene Name
PSMB5
Gene Alias
LMPX, MB1, MGC104214, X
Gene Description
proteasome (prosome, macropain) subunit, beta type, 5
Omim ID
600306Gene Ontology
HyperlinkGene Summary
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
PSX large multifunctional protease X|macropain epsilon chain|multicatalytic endopeptidase complex epsilon chain|proteasome beta 5 subunit|proteasome catalytic subunit 3|proteasome chain 6|proteasome epsilon chain|proteasome subunit MB1|proteasome subunit
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Interactome
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Pathway
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Publication Reference
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Advanced-glycation-end-product-induced formation of immunoproteasomes: involvement of RAGE and Jak2/STAT1.
Grimm S, Ott C, Hörlacher M, Weber D, Höhn A, Grune T.
The Biochemical Journal 2012 Nov; 448(1):127.
Application:WB-Ce, Mouse, RAW264.7 cells.
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Advanced-glycation-end-product-induced formation of immunoproteasomes: involvement of RAGE and Jak2/STAT1.
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