PSMB4 monoclonal antibody (M01), clone 6G7-E8
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to PSMB4 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml]
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PSMB4 is approximately 0.3ng/ml as a capture antibody.
Western Blot detection against Immunogen (54.78 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant PSMB4.
Immunogen
PSMB4 (AAH00331, 1 a.a. ~ 264 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMVTGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGYADGESFLGYVDMLGVAYEAPSLATGYGAYLAQPLLREVLEKQPVLSQTEARDLVERCMRVLYYRDARSYNRFQTATVTEKGVEIEGPLSTETNWDIAHMISGFE
Host
Mouse
Reactivity
Human
Isotype
IgG1 kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (54.78 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to PSMB4 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PSMB4 is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — PSMB4
Entrez GeneID
5692GeneBank Accession#
BC000331Protein Accession#
AAH00331Gene Name
PSMB4
Gene Alias
HN3, HsN3, PROS26
Gene Description
proteasome (prosome, macropain) subunit, beta type, 4
Omim ID
602177Gene Ontology
HyperlinkGene Summary
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. [provided by RefSeq
Other Designations
macropain beta chain|multicatalytic endopeptidase complex beta chain|proteasome beta 4 subunit|proteasome beta chain|proteasome chain 3|proteasome subunit HsN3|proteasome subunit, beta type, 4
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Interactome
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Pathway
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Disease
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Publication Reference
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Cellular PSMB4 Protein Suppresses Influenza A Virus Replication through Targeting NS1 Protein.
Chee-Hing Yang, Che-Fang Hsu, Xiang-Qing Lai, Yu-Ru Chan, Hui-Chun Li, Shih-Yen Lo.
Viruses 2022 Oct; 14(10):2277.
Application：WB, Human, A549 cell.
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Predictive value of PAK6 and PSMB4 expression in patients with localized prostate cancer treated with dose-escalation radiation therapy and androgen deprivation therapy.
Zapatero A, Morente M, Nieto S, Mart?n de Vidales C, Lopez C, Adrados M, Arellano R, Artiga MJ, Garcia-Vicente F, Herranz LM, Leaman O.
Urologic Oncology 2014 Nov; 32(8):1327.
Application：IHC-P, Human, Prostate adenocarcinoma.
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Cellular PSMB4 Protein Suppresses Influenza A Virus Replication through Targeting NS1 Protein.
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