PSMA7 (Human) IP-WB Antibody Pair
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Specification
Product Description
This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
Reactivity
Human
Interspecies Antigen Sequence
Rat (98%)
Quality Control Testing
Immunoprecipitation-Western Blot (IP-WB)
Immunoprecipitation of PSMA7 transfected lysate using mouse monoclonal anti-PSMA7 and Protein A Magnetic Bead (U0007), and immunoblotted with rabbit polyclonal anti-PSMA7.
Supplied Product
Antibody pair set content:
1. Antibody pair for IP: mouse monoclonal anti-PSMA7 (300 ug)
2. Antibody pair for WB: rabbit polyclonal anti-PSMA7 (50 ul)
Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
Immunoprecipitation-Western Blot
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Gene Info — PSMA7
Entrez GeneID
5688Gene Name
PSMA7
Gene Alias
C6, HSPC, MGC3755, RC6-1, XAPC7
Gene Description
proteasome (prosome, macropain) subunit, alpha type, 7
Omim ID
606607Gene Ontology
HyperlinkGene Summary
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. Multiple isoforms of this subunit arising from alternative splicing may exist but alternative transcripts for only two isoforms have been defined. A pseudogene has been identified on chromosome 9. [provided by RefSeq
Other Designations
OTTHUMP00000031449|proteasome alpha 7 subunit|proteasome subunit RC6-1|proteasome subunit XAPC7|proteasome subunit alpha 4
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