Products

Immunoprecipitation-Western Blot

Entrez GeneID

Gene Name

PSAP

Gene Alias

FLJ00245, GLBA, MGC110993, SAP1

Gene Description

prosaposin

Omim ID

Gene Ontology

Gene Summary

This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq

Other Designations

OTTHUMP00000019776|sphingolipid activator protein-1