PSAP (Human) Recombinant Protein (P01)
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Specification
Product Description
Human PSAP full-length ORF ( AAH01503, 18 a.a. - 524 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
PVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
81.29
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PSAP
Entrez GeneID
5660GeneBank Accession#
BC001503Protein Accession#
AAH01503Gene Name
PSAP
Gene Alias
FLJ00245, GLBA, MGC110993, SAP1
Gene Description
prosaposin
Gene Ontology
HyperlinkGene Summary
This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
OTTHUMP00000019776|sphingolipid activator protein-1
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Interactome
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Pathway
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Disease
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Publication Reference
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Analysis of lacrimal gland derived mesenchymal stem cell secretome and its impact on epithelial cell survival.
Dietrich J, Roth M, König S, Geerling G, Mertsch S, Schrader S.
Stem Cell Research 2019 Jul; 38:101477.
Application:Func, Mouse, Mouse lacrimal gland epithelial cells.
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Inducing hair follicle neogenesis with secreted proteins enriched in embryonic skin.
Fan SM, Tsai CF, Yen CM, Lin MH, Wang WH, Chan CC, Chen CL, Phua KKL, Pan SH, Plikus MV, Yu SL, Chen YJ, Lin SJ.
Biomaterials 2018 Jun; 167:121.
Application:IS, Rat, Skin.
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Mesotrypsin and Caspase-14 Participate in Prosaposin Processing - Potential Relevance to Epidermal Permeability Barrier Formation.
Yamamoto-Tanaka M, Motoyama A, Miyai M, Matsunaga Y, Matsuda J, Tsuboi R, Hibino T.
The Journal of Biological Chemistry 2014 Jul; 289(29):20026.
Application:WB-Ce, Human, Keratinocytes.
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Prosaposin, a regulator of estrogen receptor alpha, promotes breast cancer growth.
Wu Y, Sun L, Zou W, Xu J, Liu H, Wang W, Yun X, Gu J.
Cancer Science 2012 Oct; 103(10):1820.
Application:Func, Human, MCF-7, T47D cells.
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Biologically active recombinant human saposin C and PSAP.
Koochekpour, Shahriar ;Hu, Siyi.
US Patent 2010 Jan; [Epub].
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Analysis of lacrimal gland derived mesenchymal stem cell secretome and its impact on epithelial cell survival.
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