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Western Blot

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

LGMN

Gene Alias

AEP, LGMN1, PRSC1

Gene Description

legumain

Omim ID

Gene Ontology

Gene Summary

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq

Other Designations

asparaginyl endopeptidase|cysteine protease 1|protease, cysteine, 1 (legumain)