LGMN monoclonal antibody (M03), clone M2
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More Files
- More Functions
Immunoprecipitation
Immunoprecipitation of LGMN transfected lysate using anti-LGMN monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with LGMN MaxPab rabbit polyclonal antibody.
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant LGMN.
Immunogen
LGMN (AAH03061.1, 1 a.a. ~ 433 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MVWKVAVFLSVALGIGAIPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGDAEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVTHLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASEAEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHRIKLSMDHVCLGHY
Host
Mouse
Reactivity
Human
Isotype
IgG1 kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Immunoprecipitation
Immunoprecipitation of LGMN transfected lysate using anti-LGMN monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with LGMN MaxPab rabbit polyclonal antibody.ELISA
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Gene Info — LGMN
Entrez GeneID
5641GeneBank Accession#
BC003061Protein Accession#
AAH03061.1Gene Name
LGMN
Gene Alias
AEP, LGMN1, PRSC1
Gene Description
legumain
Omim ID
602620Gene Ontology
HyperlinkGene Summary
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq
Other Designations
asparaginyl endopeptidase|cysteine protease 1|protease, cysteine, 1 (legumain)
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Interactome
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Pathway
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