LGMN purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
LGMN MaxPab polyclonal antibody. Western Blot analysis of LGMN expression in human kidney.
Western Blot (Transfected lysate)
Western Blot analysis of LGMN expression in transfected 293T cell line (H00005641-T02) by LGMN MaxPab polyclonal antibody.
Lane 1: LGMN transfected lysate(47.63 KDa).
Lane 2: Non-transfected lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of purified MaxPab antibody to LGMN on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml]
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human LGMN protein.
Immunogen
LGMN (NP_001008530.1, 1 a.a. ~ 433 a.a) full-length human protein.
Sequence
MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGDAEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVTHLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASEAEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHRIKLSMDHVCLGHY
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
LGMN MaxPab polyclonal antibody. Western Blot analysis of LGMN expression in human kidney.Western Blot (Transfected lysate)
Western Blot analysis of LGMN expression in transfected 293T cell line (H00005641-T02) by LGMN MaxPab polyclonal antibody.
Lane 1: LGMN transfected lysate(47.63 KDa).
Lane 2: Non-transfected lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of purified MaxPab antibody to LGMN on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml] -
Gene Info — LGMN
Entrez GeneID
5641GeneBank Accession#
NM_001008530.1Protein Accession#
NP_001008530.1Gene Name
LGMN
Gene Alias
AEP, LGMN1, PRSC1
Gene Description
legumain
Omim ID
602620Gene Ontology
HyperlinkGene Summary
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq
Other Designations
asparaginyl endopeptidase|cysteine protease 1|protease, cysteine, 1 (legumain)
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Interactome
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Pathway
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