PROS1 (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human PROS1 full-length ORF ( AAH15801.1, 1 a.a. - 676 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MRVLGGRCGALLACLLLVLPVSEANFLSKQQASQVLVRKRRANSLLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQCSPLPCNEDGYMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPGSYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKSCEDIDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPEISRFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGLLETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVEKGSYYPGSGIAQFHIDYNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTSEKSQDILLSVENTVIYRIQALSLCSDQQSHLEFRVNRNNLELSTPLKIETISHEDLQRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFYNGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWKKTKNS
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
101.5
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PROS1
Entrez GeneID
5627GeneBank Accession#
BC015801.1Protein Accession#
AAH15801.1Gene Name
PROS1
Gene Alias
PROS, PS21, PS22, PS23, PS24, PS25, PSA
Gene Description
protein S (alpha)
Omim ID
176880Gene Ontology
HyperlinkGene Summary
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq
Other Designations
protein S, alpha|protein Sa
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Interactome
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Pathway
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Disease
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Publication Reference
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Gas6 Promotes Microglia Efferocytosis and Suppresses Inflammation Through Activating Axl/Rac1 Signaling in Subarachnoid Hemorrhage Mice.
Junjia Tang, Yichao Jin, Feng Jia, Tao Lv, Anatol Manaenko, Lin-Feng Zhang, Zeyu Zhang, Xin Qi, Yajun Xue, Bin Zhao, Xiaohua Zhang, John H Zhang, Jianfei Lu, Qin Hu.
Translational Stroke Research 2022 Nov; [Epub].
Application：Sub, Mouse, Mouse brain cortex.
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Tyro3 is a podocyte protective factor in glomerular disease.
Zhong F, Chen Z, Zhang L, Xie Y, Nair V, Ju W, Kretzler M, Nelson RG, Li Z, Chen H, Wang Y, Zhang A, Lee K, Liu Z, He JC.
JCI Insight 2018 Nov; 3(22):123482.
Application：Func, Human, Human podocytes.
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Gas6 Promotes Microglia Efferocytosis and Suppresses Inflammation Through Activating Axl/Rac1 Signaling in Subarachnoid Hemorrhage Mice.
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