PROC 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-PROC full-length
Host
Human
Theoretical MW (kDa)
50.82
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-PROC antibody (H00005624-B01) by Western Blots.
Western Blot
Lane 1: PROC transfected lysate ( 52.1 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
PROC transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — PROC
Entrez GeneID
5624GeneBank Accession#
NM_000312Protein Accession#
NP_000303Gene Name
PROC
Gene Alias
PC, PROC1
Gene Description
protein C (inactivator of coagulation factors Va and VIIIa)
Omim ID
176860Gene Ontology
HyperlinkGene Summary
The PROC gene encodes protein C (EC 3.4.21.69), a vitamin K-dependent plasma glycoprotein that is a key component of the anticoagulant system. Protein C is cleaved to its activated form, 'activated protein C' (APC) on endothelial cells by the thrombin-thrombomodulin complex (MIM 176930; MIM 188040) and then acts as a serine protease to degrade the activated forms of coagulation factors V (F5; MIM 612309) and VIII (F8; see MIM 306700). Protein S (PROS1; MIM 176880), also a vitamin K-dependent plasma protein, functions as a cofactor to activated protein C.[supplied by OMIM
Other Designations
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Interactome
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Pathway
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Disease
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