Products

Western Blot (Tissue lysate)

Western Blot (Transfected lysate)

Immunofluorescence

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

MAP2K2

Gene Alias

FLJ26075, MAPKK2, MEK2, MKK2, PRKMK2

Gene Description

mitogen-activated protein kinase kinase 2

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq

Other Designations

ERK activator kinase 2|MAP kinase kinase 2|MAPK/ERK kinase 2|dual specificity mitogen-activated protein kinase kinase 2|mitogen-activated protein kinase kinase 2, p45