Proximity Ligation Analysis of protein-protein interactions between MAPK11 and MAP3K7IP1. HeLa cells were stained with anti-MAPK11 rabbit purified polyclonal 1:1200 and anti-MAP3K7IP1 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. [provided by RefSeq
OTTHUMP00000196655,mitogen-activated protein kinase p38 beta,mitogen-activated protein kinase p38-2,stress-activated protein kinase-2,stress-activated protein kinase-2b