PRKDC (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human PRKDC partial ORF ( NP_008835, 4019 a.a. - 4128 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
KMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGREPWM
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.84
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PRKDC
Entrez GeneID
5591GeneBank Accession#
NM_006904Protein Accession#
NP_008835Gene Name
PRKDC
Gene Alias
DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350
Gene Description
protein kinase, DNA-activated, catalytic polypeptide
Omim ID
600899Gene Ontology
HyperlinkGene Summary
The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.[supplied by OMIM
Other Designations
hyper-radiosensitivity of murine scid mutation, complementing 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Mutual regulation between DNA-PKcs and snail1 leads to increased genomic instability and aggressive tumor characteristics.
Pyun BJ, Seo HR, Lee HJ, Jin YB, Kim EJ, Kim NH, Kim HS, Nam HW, Yook JI, Lee YS.
Cell Death and Disease 2013 Feb; 4:e517.
Application:Func, Human, NCI-H460 cells, DLD-1 cells.
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Mutual regulation between DNA-PKcs and snail1 leads to increased genomic instability and aggressive tumor characteristics.
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