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Western Blot

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

PRKAR2A

Gene Alias

MGC3606, PKR2, PRKAR2

Gene Description

protein kinase, cAMP-dependent, regulatory, type II, alpha

Omim ID

Gene Ontology

Gene Summary

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq

Other Designations

cAMP-dependent protein kinase regulatory subunit RII alpha|cAMP-dependent protein kinase, regulatory subunit alpha 2|protein kinase A, RII-alpha subunit