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PRKAR1A mouse monoclonal antibody (hybridoma)

  • Catalog # : H00005573-M
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against a full-length recombinant PRKAR1A.
  • Immunogen:
  • PRKAR1A (NP_002725.1, 1 a.a. ~ 381 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
  • Sequence:
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Antibody reactivity and specificity confirmed by ELISA and Western Blot.
  • Note:
  • Customer should check the viability of the hybridomas within one month from the date of receipt. Fee-for-service of long term hybridoma storage can be performed upon customer's request.
  • Deliverables:
  • Up to 5 positive hybridoma clones will be delivered to customer in the cryotube format.
  • Applications
  • Application Image
  • Western Blot (Transfected lysate)
  • Western Blot (Recombinant protein)
  • Gene Information
  • Entrez GeneID:
  • 5573
  • Gene Name:
  • Gene Alias:
  • Gene Description:
  • protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
  • Gene Summary:
  • cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq
  • Other Designations:
  • cAMP-dependent protein kinase regulatory subunit RIalpha,cAMP-dependent protein kinase type I-alpha regulatory chain,cAMP-dependent protein kinase, regulatory subunit alpha 1,protein kinase A type 1a regulatory subunit,tissue-specific extinguisher 1
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