PRKAB2 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Western Blot
Lane 1: PRKAB2 transfected lysate ( 30.3 KDa)
Lane 2: Non-transfected lysate.
SDS-PAGE Gel
PRKAB2 transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-PRKAB2 full-length
Host
Human
Theoretical MW (kDa)
30.03
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-PRKAB2 antibody (H00005565-B01) by Western Blots.
Western Blot
Lane 1: PRKAB2 transfected lysate ( 30.3 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
PRKAB2 transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — PRKAB2
Entrez GeneID
5565GeneBank Accession#
NM_005399Protein Accession#
NP_005390Gene Name
PRKAB2
Gene Alias
MGC61468
Gene Description
protein kinase, AMP-activated, beta 2 non-catalytic subunit
Omim ID
602741Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. [provided by RefSeq
Other Designations
5'-AMP-activated protein kinase, beta-2 subunit|AMP-activated protein kinase beta 2 non-catalytic subunit|AMPK beta 2|AMPK beta-2 chain|OTTHUMP00000015910
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Interactome
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