PRF1 MaxPab rabbit polyclonal antibody (D01)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of PRF1 expression in transfected 293T cell line (H00005551-T02) by PRF1 MaxPab polyclonal antibody.
Lane 1: PRF1 transfected lysate(61.40 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of PRF1 transfected lysate using anti-PRF1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with PRF1 purified MaxPab mouse polyclonal antibody (B01P) (H00005551-B01P).
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human PRF1 protein.
Immunogen
PRF1 (NP_005032.2, 1 a.a. ~ 555 a.a) full-length human protein.
Sequence
MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPVDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARDAARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREALRRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRLQVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQMLLGEPPGNRSGAVW
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Mouse (69); Rat (69)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of PRF1 expression in transfected 293T cell line (H00005551-T02) by PRF1 MaxPab polyclonal antibody.
Lane 1: PRF1 transfected lysate(61.40 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of PRF1 transfected lysate using anti-PRF1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with PRF1 purified MaxPab mouse polyclonal antibody (B01P) (H00005551-B01P). -
Gene Info — PRF1
Entrez GeneID
5551GeneBank Accession#
NM_005041Protein Accession#
NP_005032.2Gene Name
PRF1
Gene Alias
FLH2, HPLH2, MGC65093, P1, PFN1, PFP
Gene Description
perforin 1 (pore forming protein)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq
Other Designations
OTTHUMP00000019759|cytolysin|lymphocyte pore forming protein|perforin 1
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Interactome
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Pathway
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Disease
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