Products

Western Blot (Transfected lysate)

Immunofluorescence (Transfected cell)

Flow Cytometry (Transfected cell)

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

PRELP

Gene Alias

MGC45323, MST161, MSTP161, SLRR2A

Gene Description

proline/arginine-rich end leucine-rich repeat protein

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq

Other Designations

55 kDa leucine-rich repeat protein of articular cartilage|OTTHUMP00000034099|prolargin proteoglycan|proline arginine-rich end leucine-rich repeat protein