PRELP rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human PRELP peptide using ARM Technology.
Immunogen
A synthetic peptide of human PRELP is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human PRELP peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — PRELP
Entrez GeneID
5549GeneBank Accession#
PRELPGene Name
PRELP
Gene Alias
MGC45323, MST161, MSTP161, SLRR2A
Gene Description
proline/arginine-rich end leucine-rich repeat protein
Omim ID
601914Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq
Other Designations
55 kDa leucine-rich repeat protein of articular cartilage|OTTHUMP00000034099|prolargin proteoglycan|proline arginine-rich end leucine-rich repeat protein
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Interactome
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Disease
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