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Last updated: 2017/8/20

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PRCP rabbit monoclonal antibody

  • Catalog # : H00005547-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human PRCP peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human PRCP is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human PRCP peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 5547
  • GeneBank Accession#:
  • PRCP
  • Gene Name:
  • PRCP
  • Gene Alias:
  • HUMPCP,MGC2202,PCP
  • Gene Description:
  • prolylcarboxypeptidase (angiotensinase C)
  • Gene Summary:
  • The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
  • Other Designations:
  • angiotensinase C,lysosomal Pro-x carboxypeptidase,lysosomal carboxypeptidase C,proline carboxypeptidase,prolylcarboxypeptidase,prolylcarboxypeptidase isoform 1 preproprotein
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