PRCP purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of PRCP expression in transfected 293T cell line (H00005547-T02) by PRCP MaxPab polyclonal antibody.
Lane 1: PRCP transfected lysate(55.80 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human PRCP protein.
Immunogen
PRCP (NP_005031.1, 1 a.a. ~ 496 a.a) full-length human protein.
Sequence
MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Mouse (78); Rat (79)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of PRCP expression in transfected 293T cell line (H00005547-T02) by PRCP MaxPab polyclonal antibody.
Lane 1: PRCP transfected lysate(55.80 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — PRCP
Entrez GeneID
5547GeneBank Accession#
NM_005040Protein Accession#
NP_005031.1Gene Name
PRCP
Gene Alias
HUMPCP, MGC2202, PCP
Gene Description
prolylcarboxypeptidase (angiotensinase C)
Omim ID
176785Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
Other Designations
angiotensinase C|lysosomal Pro-x carboxypeptidase|lysosomal carboxypeptidase C|proline carboxypeptidase|prolylcarboxypeptidase|prolylcarboxypeptidase isoform 1 preproprotein
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Interactome
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Disease
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