PPP3CC (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human PPP3CC full-length ORF ( NP_005596.2, 1 a.a. - 512 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MSGRRFHLSTTDRVIKAVPFPPTQRLTFKEVFENGKPKVDVLKNHLVKEGRLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELISDDEAEGSTTVRKEIIRNKIRAIGKMARVFSILRQESESVLTLKGLTPTGTLPLGVLSGGKQTIETATVEAVEAREAIRGFSLQHKIRSFEEARGLDRINERMPPRKDSIHAGGPMKSVTSAHSHAAHRSDQGKKAHS
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
84.5
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PPP3CC
Entrez GeneID
5533GeneBank Accession#
NM_005605.3Protein Accession#
NP_005596.2Gene Name
PPP3CC
Gene Alias
CALNA3
Gene Description
protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform
Omim ID
114107Gene Ontology
HyperlinkGene Summary
Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1; MIM 114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).[supplied by OMIM
Other Designations
calcineurin A gamma
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Interactome
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Pathway
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Disease
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Publication Reference
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Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation.
Chaya T, Tsutsumi R, Varner LR, Maeda Y, Yoshida S, Furukawa T.
The EMBO Journal 2019 Dec; 38(23):e101409.
Application：PA, Human, Recombinant protein.
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Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation.
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