PPP2R2B (Human) Recombinant Protein (Q02)
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More Files
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Specification
Product Description
Human PPP2R2B partial ORF ( AAH31790.1, 22 a.a. - 128 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
TEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPE
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.4
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PPP2R2B
Entrez GeneID
5521GeneBank Accession#
BC031790Protein Accession#
AAH31790.1Gene Name
PPP2R2B
Gene Alias
B55-BETA, FLJ95686, MGC24888, PP2A-B55BETA, PP2A-PR55B, PP2AB-BETA, PP2APR55-BETA, PR2AB-BETA, PR2AB55-BETA, PR2APR55-BETA, PR52B, PR55-BETA, SCA12
Gene Description
protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform
Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. [provided by RefSeq
Other Designations
PP2A, subunit B, B-beta isoform|PP2A, subunit B, R2-beta isoform|beta isoform of regulatory subunit B55, protein phosphatase 2|protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform|serine/threonine protein phosphatase 2A, 55 kDa
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Interactome
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Pathway
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Disease
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