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PPP2R2B rabbit monoclonal antibody

  • Catalog # : H00005521-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human PPP2R2B peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human PPP2R2B is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human PPP2R2B peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 5521
  • Gene Name:
  • PPP2R2B
  • Gene Alias:
  • B55-BETA,FLJ95686,MGC24888,PP2A-B55BETA,PP2A-PR55B,PP2AB-BETA,PP2APR55-BETA,PR2AB-BETA,PR2AB55-BETA,PR2APR55-BETA,PR52B,PR55-BETA,SCA12
  • Gene Description:
  • protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform
  • Gene Summary:
  • The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. [provided by RefSeq
  • Other Designations:
  • PP2A, subunit B, B-beta isoform,PP2A, subunit B, R2-beta isoform,beta isoform of regulatory subunit B55, protein phosphatase 2,protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform,serine/threonine protein phosphatase 2A, 55 kDa
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