PPP2R2B purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human PPP2R2B protein.
Immunogen
PPP2R2B (NP_004567.1, 1 a.a. ~ 443 a.a) full-length human protein.
Sequence
MEEDIDTRKINNSFLRDHSYATEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN
Host
Rabbit
Reactivity
Human, Mouse
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
PPP2R2B MaxPab rabbit polyclonal antibody. Western Blot analysis of PPP2R2B expression in mouse spleen.Western Blot (Tissue lysate)
PPP2R2B MaxPab rabbit polyclonal antibody. Western Blot analysis of PPP2R2B expression in human spleen.Western Blot (Cell lysate)
PPP2R2B MaxPab rabbit polyclonal antibody. Western Blot analysis of PPP2R2B expression in HepG2.Western Blot (Transfected lysate)
Western Blot analysis of PPP2R2B expression in transfected 293T cell line (H00005521-T02) by PPP2R2B MaxPab polyclonal antibody.
Lane 1: PPP2R2B transfected lysate(51.70 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — PPP2R2B
Entrez GeneID
5521GeneBank Accession#
NM_004576.2Protein Accession#
NP_004567.1Gene Name
PPP2R2B
Gene Alias
B55-BETA, FLJ95686, MGC24888, PP2A-B55BETA, PP2A-PR55B, PP2AB-BETA, PP2APR55-BETA, PR2AB-BETA, PR2AB55-BETA, PR2APR55-BETA, PR52B, PR55-BETA, SCA12
Gene Description
protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform
Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. [provided by RefSeq
Other Designations
PP2A, subunit B, B-beta isoform|PP2A, subunit B, R2-beta isoform|beta isoform of regulatory subunit B55, protein phosphatase 2|protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform|serine/threonine protein phosphatase 2A, 55 kDa
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Interactome
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Pathway
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Disease
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