Products

Immunoprecipitation-Western Blot

Entrez GeneID

Gene Name

PPP2R1B

Gene Alias

MGC26454, PR65B

Gene Description

protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform

Omim ID

Gene Ontology

Gene Summary

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Defects in this gene could be the cause of some lung and colon cancers. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

PP2A, subunit A, PR65-beta isoform|PP2A, subunit A, R1-beta isoform|PP2A-A-beta|beta isoform of regulatory subunit A, protein phosphatase 2|protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform|protein phosphatase 2, structural/r