PPM1A 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Western Blot
Lane 1: PPM1A transfected lysate ( 42.4 KDa)
Lane 2: Non-transfected lysate.
SDS-PAGE Gel
PPM1A transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-PPM1A full-length
Host
Human
Theoretical MW (kDa)
42.13
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-PPM1A antibody (H00005494-B01) by Western Blots.
Western Blot
Lane 1: PPM1A transfected lysate ( 42.4 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
PPM1A transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — PPM1A
Entrez GeneID
5494GeneBank Accession#
NM_021003Protein Accession#
NP_066283Gene Name
PPM1A
Gene Alias
FLJ42306, MGC9201, PP2C-ALPHA, PP2CA
Gene Description
protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
Omim ID
606108Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
Other Designations
protein phosphatase 1A|protein phosphatase 2C alpha isoform
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Interactome
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Pathway
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Disease
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