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PPM1A 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00005494-T01
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-PPM1A full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 42.13
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-PPM1A antibody (H00005494-B01) by Western Blots.
    Western Blot
    QC Testing of H00005494-T01
    Lane 1: PPM1A transfected lysate ( 42.4 KDa)
    Lane 2: Non-transfected lysate.
    SDS-PAGE Gel
    QC Testing of H00005494-T01
    PPM1A transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 5494
  • Gene Name:
  • PPM1A
  • Gene Alias:
  • FLJ42306,MGC9201,PP2C-ALPHA,PP2CA
  • Gene Description:
  • protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
  • Gene Summary:
  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
  • Other Designations:
  • protein phosphatase 1A,protein phosphatase 2C alpha isoform
  • Gene Pathway
  • Related Disease
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