PPID (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human PPID full-length ORF ( NP_005029.1, 1 a.a. - 370 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MSHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGHTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGRNTNGSQFFITTVPTPHLDGKHVVFGQVIKGIGVARILENVEVKGEKPAKLCVIAECGELKEGDDGGIFPKDGSGDSHPDFPEDADIDLKDVDKILLITEDLKNIGNTFFKSQNWEMAIKKYAEVLRYVDSSKAVIETADRAKLQPIALSCVLNIGACKLKMSNWQGAIDSCLEALELDPSNTKALYRRAQGWQGLKEYDQALADLKKAQGIAPEDKAIQAELLKVKQKIKAQKDKEKAVYAKMFA
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
67.2
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PPID
Entrez GeneID
5481GeneBank Accession#
NM_005038.2Protein Accession#
NP_005029.1Gene Name
PPID
Gene Alias
CYP-40, CYPD, MGC33096
Gene Description
peptidylprolyl isomerase D
Omim ID
601753Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq
Other Designations
40 kDa peptidyl-prolyl cis-trans isomerase D|PPIase|cyclophilin 40|cyclophilin D|cyclophilin-related protein|rotamase
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Interactome
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Pathway
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Publication Reference
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Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore.
Nguyen TT, Stevens MV, Kohr M, Steenbergen C, Sack MN, Murphy E.
The Journal of Biological Chemistry 2011 Nov; 286(46):40184.
Application：Func, Compound.
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Complement 1q binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death.
McGee AM, Baines CP.
The Biochemical Journal 2011 Jan; 433(1):119.
Application：Func, PI, WB-Re, Mouse, Mouse cardiac mitochondrial lysates, Recombinant protein.
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Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore.
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