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POMC (Human) IP-WB Antibody Pair

  • Catalog # : H00005443-PW1
  • Visit Frequency :
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  • Specification
  • Product Description:
  • This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Immunoprecipitation-Western Blot (IP-WB)

    QC Testing of H00005443-PW1
    Immunoprecipitation of POMC transfected lysate using rabbit polyclonal anti-POMC and Protein A Magnetic Bead (U0007), and immunoblotted with mouse polyclonal anti-POMC.
  • Supplied Product:
  • Antibody pair set content:
    1. Antibody pair for IP: rabbit polyclonal anti-POMC (300 ul)
    2. Antibody pair for WB: mouse polyclonal anti-POMC (50 ul)
  • Storage Instruction:
  • Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
  • Applications
  • Application Image
  • Immunoprecipitation-Western Blot
  • Gene Information
  • Entrez GeneID:
  • 5443
  • Gene Name:
  • POMC
  • Gene Alias:
  • ACTH,CLIP,LPH,MSH,NPP,POC
  • Gene Description:
  • proopiomelanocortin
  • Gene Summary:
  • This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000119991,adrenocorticotropic hormone,adrenocorticotropin,alpha-MSH,alpha-melanocyte-stimulating hormone,beta-LPH,beta-MSH,beta-endorphin,beta-melanocyte-stimulating hormone,corticotropin-like intermediary peptide,gamma-LPH,gamma-MSH,lipotropin b
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