Immunoprecipitation of POLR2E transfected lysate using anti-POLR2E MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with POLR2E purified MaxPab mouse polyclonal antibody (B01P) (H00005434-B01P).
This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. [provided by RefSeq
DNA directed RNA polymerase II 23 kda polypeptide,DNA directed RNA polymerase II polypeptide E,polymerase (RNA) II (DNA directed) polypeptide E (25kD)