POLH 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
- More Functions
SDS-PAGE Gel
POLH transfected lysate.
Western Blot
Lane 1: POLH transfected lysate ( 78.4 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-POLH full-length
Host
Human
Theoretical MW (kDa)
78.4
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-POLH antibody (H00005429-B01) by Western Blots.
SDS-PAGE Gel
POLH transfected lysate.
Western Blot
Lane 1: POLH transfected lysate ( 78.4 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — POLH
Entrez GeneID
5429GeneBank Accession#
NM_006502.1Protein Accession#
-Gene Name
POLH
Gene Alias
FLJ16395, FLJ21978, RAD30, RAD30A, XP-V, XPV
Gene Description
polymerase (DNA directed), eta
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. [provided by RefSeq
Other Designations
OTTHUMP00000016478|OTTHUMP00000039868
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Interactome
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Disease
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