PMS2 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human PMS2 partial ORF ( NP_000526, 763 a.a. - 862 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
ERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.74
Interspecies Antigen Sequence
Mouse (95)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PMS2
Entrez GeneID
5395GeneBank Accession#
NM_000535Protein Accession#
NP_000526Gene Name
PMS2
Gene Alias
HNPCC4, PMS2CL, PMSL2
Gene Description
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
Gene Ontology
HyperlinkGene Summary
This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq
Other Designations
DNA mismatch repair protein|H_DJ0042M02.9|PMS2 postmeiotic segregation increased 2|mismatch repair endonuclease|postmeiotic segregation increased 2
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Interactome
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