PMS2 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human PMS2 peptide using ARM Technology.
Immunogen
A synthetic peptide of human PMS2 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human PMS2 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — PMS2
Entrez GeneID
5395GeneBank Accession#
PMS2Gene Name
PMS2
Gene Alias
HNPCC4, PMS2CL, PMSL2
Gene Description
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
Gene Ontology
HyperlinkGene Summary
This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq
Other Designations
DNA mismatch repair protein|H_DJ0042M02.9|PMS2 postmeiotic segregation increased 2|mismatch repair endonuclease|postmeiotic segregation increased 2
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