PLOD2 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-PLOD2 full-length
Host
Human
Theoretical MW (kDa)
83.49
Interspecies Antigen Sequence
Mouse (91); Rat (91)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-PLOD2 antibody (H00005352-B01) by Western Blots.
SDS-PAGE Gel
PLOD2 transfected lysate.
Western Blot
Lane 1: PLOD2 transfected lysate ( 83.49 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — PLOD2
Entrez GeneID
5352GeneBank Accession#
NM_182943.2Protein Accession#
NP_891988.1Gene Name
PLOD2
Gene Alias
LH2, TLH
Gene Description
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
lysine hydroxylase 2|lysyl hydroxylase 2|telopeptide lysyl hydroxylase
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Interactome
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