PLAT 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-PLAT full-length
Host
Human
Theoretical MW (kDa)
62.9
Interspecies Antigen Sequence
Mouse (80); Rat (82)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-PLAT antibody (H00005327-B01) by Western Blots.
SDS-PAGE Gel
PLAT transfected lysate.
Western Blot
Lane 1: PLAT transfected lysate ( 62.9 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — PLAT
Entrez GeneID
5327GeneBank Accession#
NM_000930.2Protein Accession#
NP_000921.1Gene Name
PLAT
Gene Alias
DKFZp686I03148, T-PA, TPA
Gene Description
plasminogen activator, tissue
Omim ID
173370Gene Ontology
HyperlinkGene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
alteplase|plasminogen activator, tissue type|reteplase|t-plasminogen activator|tissue plasminogen activator (t-PA)
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Interactome
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Pathway
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Disease
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