PLAT (Human) IP-WB Antibody Pair
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Specification
Product Description
This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
Reactivity
Human
Interspecies Antigen Sequence
Mouse (80%); Rat (81%)
Quality Control Testing
Immunoprecipitation-Western Blot (IP-WB)
Immunoprecipitation of PLAT transfected lysate using rabbit polyclonal anti-PLAT and Protein A Magnetic Bead (U0007), and immunoblotted with mouse polyclonal anti-PLAT.
Supplied Product
Antibody pair set content:
1. Antibody pair for IP: rabbit polyclonal anti-PLAT (300 ul)
2. Antibody pair for WB: mouse polyclonal anti-PLAT (50 ul)
Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
Immunoprecipitation-Western Blot
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Gene Info — PLAT
Entrez GeneID
5327Gene Name
PLAT
Gene Alias
DKFZp686I03148, T-PA, TPA
Gene Description
plasminogen activator, tissue
Omim ID
173370Gene Ontology
HyperlinkGene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
alteplase|plasminogen activator, tissue type|reteplase|t-plasminogen activator|tissue plasminogen activator (t-PA)
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Interactome
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Pathway
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Disease
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