PLA2G4A (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human PLA2G4A partial ORF ( NP_077734, 1 a.a. - 110 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVS
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.84
Interspecies Antigen Sequence
Mouse (98); Rat (98)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PLA2G4A
Entrez GeneID
5321GeneBank Accession#
NM_024420Protein Accession#
NP_077734Gene Name
PLA2G4A
Gene Alias
MGC126350, PLA2G4, cPLA2-alpha
Gene Description
phospholipase A2, group IVA (cytosolic, calcium-dependent)
Omim ID
600522Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq
Other Designations
OTTHUMP00000033543|calcium-dependent phospholipid-binding protein|cytosolic phospholipase A2, group IVA|lysophospholipase|phosphatidylcholine 2-acylhydrolase
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Interactome
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