PKP1 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human PKP1 peptide using ARM Technology.
Immunogen
A synthetic peptide of human PKP1 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human PKP1 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — PKP1
Entrez GeneID
5317GeneBank Accession#
PKP1Gene Name
PKP1
Gene Alias
B6P, MGC138829
Gene Description
plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. [provided by RefSeq
Other Designations
OTTHUMP00000033848|OTTHUMP00000033849|band 6 protein|plakophilin 1
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Interactome
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Disease
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