PKLR purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Western Blot (Tissue lysate)
PKLR MaxPab polyclonal antibody. Western Blot analysis of PKLR expression in human liver.
Western Blot (Transfected lysate)
Western Blot analysis of PKLR expression in transfected 293T cell line (H00005313-T01) by PKLR MaxPab polyclonal antibody.
Lane 1: PKLR transfected lysate(63.14 KDa).
Lane 2: Non-transfected lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of purified MaxPab antibody to PKLR on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml]
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human PKLR protein.
Immunogen
PKLR (NP_000289.1, 1 a.a. ~ 574 a.a) full-length human protein.
Sequence
MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
PKLR MaxPab polyclonal antibody. Western Blot analysis of PKLR expression in human liver.Western Blot (Transfected lysate)
Western Blot analysis of PKLR expression in transfected 293T cell line (H00005313-T01) by PKLR MaxPab polyclonal antibody.
Lane 1: PKLR transfected lysate(63.14 KDa).
Lane 2: Non-transfected lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of purified MaxPab antibody to PKLR on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml] -
Gene Info — PKLR
Entrez GeneID
5313GeneBank Accession#
NM_000298.4Protein Accession#
NP_000289.1Gene Name
PKLR
Gene Alias
PK1, PKL, PKR, PKRL, RPK
Gene Description
pyruvate kinase, liver and RBC
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
R-type/L-type pyruvate kinase|pyruvate kinase 1|pyruvate kinase isozyme R/L|pyruvate kinase type L|pyruvate kinase, liver and RBC type|pyruvate kinase, liver and blood cell|red cell/liver pyruvate kinase
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Interactome
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Pathway
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Disease
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