Products

ELISA

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

PIK3C2A

Gene Alias

CPK, DKFZp686L193, MGC142218, PI3-K-C2(ALPHA), PI3-K-C2A

Gene Description

phosphoinositide-3-kinase, class 2, alpha polypeptide

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq

Other Designations

C2-containing phosphatidylinositol kinase|PI3K-C2alpha