PI3 (Human) Recombinant Protein
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Specification
Product Description
Purified PI3 (NP_002629.1, 61 a.a. - 117 a.a.) human recombinant protein with His-Flag-StrepII tag at N-terminus expressed in human cells.
Transfected Cell Line
Human HEK293T cells
Sequence
AQEPVKGPVSTKPGSCPIILIRCAMLNPPNRCLKDTDCPGIKKCCEGSCGMACFVPQ
Host
Human
Theoretical MW (kDa)
11.55
Form
Liquid
Preparation Method
Transfection of pSuper-PI3 plasmid into HEK293T cell, and the expressed protein was purified by Strep-Tactin affinity column.
Purification
Strep-Tactin affinity columns
Concentration
≥ 10 ug/ml
Quality Control Testing
SDS-PAGE
Storage Buffer
100 mM Tris-HCl pH 8.0, 150 mM NaCl, 1 mM EDTA, and 5 mM desthiobiotin.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
SDS-PAGE
Protein Interaction
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Gene Info — PI3
Entrez GeneID
5266GeneBank Accession#
NM_002638.2Protein Accession#
NP_002629.1Gene Name
PI3
Gene Alias
ESI, MGC13613, SKALP, WAP3, WFDC14, cementoin
Gene Description
peptidase inhibitor 3, skin-derived
Omim ID
182257Gene Ontology
HyperlinkGene Summary
This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq
Other Designations
OTTHUMP00000031100|WAP four-disulfide core domain 14|elafin|elastase-specific inhibitor|protease inhibitor 3, skin-derived (SKALP)|skin-derived antileukoproteinase
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Interactome
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Disease
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