Western blot analysis of PGD over-expressed 293 cell line, cotransfected with PGD Validated Chimera RNAi ( Cat # H00005226-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with PGD monoclonal antibody (M01), clone 1G12 (Cat # H00005226-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. [provided by RefSeq