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PFKFB2 rabbit monoclonal antibody

  • Catalog # : H00005208-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human PFKFB2 peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human PFKFB2 is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human PFKFB2 peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 5208
  • Gene Name:
  • PFKFB2
  • Gene Alias:
  • DKFZp781D2217,MGC138308,MGC138310,PFK-2/FBPase-2
  • Gene Description:
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
  • Gene Summary:
  • The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2,6PF-2-K/Fru-2,6-P2ASE heart-type isozyme,OTTHUMP00000034285,OTTHUMP00000034286,PFKFB, cardiac,fructose-2,6-bisphosphatase, cardiac isozyme
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