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PFKFB1 rabbit monoclonal antibody

  • Catalog # : H00005207-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human PFKFB1 peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human PFKFB1 is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human PFKFB1 peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • Application Image
  • Western Blot (Transfected lysate)
  • Gene Information
  • Entrez GeneID:
  • 5207
  • Gene Name:
  • PFKFB1
  • Gene Alias:
  • F6PK,HL2K,MGC116715,MGC116717,PFRX
  • Gene Description:
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
  • Gene Summary:
  • This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. [provided by RefSeq
  • Other Designations:
  • 6PF-2-K/Fru-2,6-P2ASE liver isozyme,OTTHUMP00000023391,fructose-2,6-bisphosphatase,fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase
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