PFKFB1 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human PFKFB1 peptide using ARM Technology.
Immunogen
A synthetic peptide of human PFKFB1 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human PFKFB1 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — PFKFB1
Entrez GeneID
5207GeneBank Accession#
PFKFB1Gene Name
PFKFB1
Gene Alias
F6PK, HL2K, MGC116715, MGC116717, PFRX
Gene Description
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Omim ID
311790Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. [provided by RefSeq
Other Designations
6PF-2-K/Fru-2,6-P2ASE liver isozyme|OTTHUMP00000023391|fructose-2,6-bisphosphatase|fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase
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