PDE8A 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
PDE8A transfected lysate.
Western Blot
Lane 1: PDE8A transfected lysate ( 91.3 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-PDE8A full-length
Host
Human
Theoretical MW (kDa)
91.3
Interspecies Antigen Sequence
Mouse (79); Rat (78)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-PDE8A antibody (H00005151-B01) by Western Blots.
SDS-PAGE Gel
PDE8A transfected lysate.
Western Blot
Lane 1: PDE8A transfected lysate ( 91.3 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — PDE8A
Entrez GeneID
5151GeneBank Accession#
NM_002605.2Protein Accession#
NP_002596.1Gene Name
PDE8A
Gene Alias
FLJ16150, HsT19550
Gene Description
phosphodiesterase 8A
Omim ID
602972Gene Ontology
HyperlinkGene Summary
Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., MIM 2000). See MIM 171885.[supplied by OMIM
Other Designations
OTTHUMP00000192898|cAMP-specific cyclic nucleotide phosphodiesterase 8A|high-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
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Interactome
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