PCMT1 monoclonal antibody (M01), clone 4G9
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More Files
- More Functions
Western Blot (Cell lysate)
PCMT1 monoclonal antibody (M01), clone 4G9 Western Blot analysis of PCMT1 expression in PC-12 ( Cat # L012V1 ).
Western Blot detection against Immunogen (50.82 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant PCMT1.
Immunogen
PCMT1 (AAH07501.1, 1 a.a. ~ 228 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNPYMDSPQSIGFQATISAPHMHAYALELLFDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKDDPTLLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPAGGNQMLEQYDKLQDGSIKMKPLMGVIYVPLTDKEKQWSRDEL
Host
Mouse
Reactivity
Human, Rat
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (50.82 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
PCMT1 monoclonal antibody (M01), clone 4G9 Western Blot analysis of PCMT1 expression in PC-12 ( Cat # L012V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — PCMT1
Entrez GeneID
5110GeneBank Accession#
BC007501Protein Accession#
AAH07501.1Gene Name
PCMT1
Gene Alias
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Gene Description
protein-L-isoaspartate (D-aspartate) O-methyltransferase
Omim ID
176851Gene Ontology
HyperlinkGene Summary
Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.[supplied by OMIM
Other Designations
L-isoaspartyl/D-aspartyl methyltransferase|OTTHUMP00000017398|OTTHUMP00000017400
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Interactome
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Disease
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