PCCA purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Western Blot (Tissue lysate)
PCCA MaxPab polyclonal antibody. Western Blot analysis of PCCA expression in human liver.
Western Blot (Cell lysate)
PCCA MaxPab polyclonal antibody. Western Blot analysis of PCCA expression in U-2 OS.
Western Blot (Transfected lysate)
Western Blot analysis of PCCA expression in transfected 293T cell line (H00005095-T01) by PCCA MaxPab polyclonal antibody.
Lane 1: PCCA transfected lysate(77.33 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human PCCA protein.
Immunogen
PCCA (AAH00140.1, 1 a.a. ~ 703 a.a) full-length human protein.
Sequence
MLSAALRTLKHVLYYSRQCLMVSRNLGSVGYDPNEKTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTHNIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGEGDLLVELE
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (91); Rat (90)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
PCCA MaxPab polyclonal antibody. Western Blot analysis of PCCA expression in human liver.Western Blot (Cell lysate)
PCCA MaxPab polyclonal antibody. Western Blot analysis of PCCA expression in U-2 OS.Western Blot (Transfected lysate)
Western Blot analysis of PCCA expression in transfected 293T cell line (H00005095-T01) by PCCA MaxPab polyclonal antibody.
Lane 1: PCCA transfected lysate(77.33 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — PCCA
Entrez GeneID
5095GeneBank Accession#
BC000140.2Protein Accession#
AAH00140.1Gene Name
PCCA
Gene Alias
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Gene Description
propionyl Coenzyme A carboxylase, alpha polypeptide
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000018635|PCCase alpha subunit|pccA complementation group|propanoyl-CoA:carbon dioxide ligase alpha subunit|propionyl-CoA carboxylase alpha chain, mitochondrial|propionyl-Coenzyme A carboxylase, alpha polypeptide
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Interactome
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Pathway
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Disease
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Publication Reference
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Ataxin-2 (Atxn2)-Knock-Out Mice Show Branched Chain Amino Acids and Fatty Acids Pathway Alterations.
Meierhofer D, Halbach M, Şen NE, Gispert S, Auburger G.
Molecular & Cellular proteomics: MCP 2016 Feb; 15(5):1728.
Application：WB-Ti, Mouse, Mouse liver.
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Folding and activity of mutant cystathionine β-synthase depends on the position and nature of the purification tag: characterization of the R266K CBS mutant.
Majtan T, Kraus JP.
Protein Expression and Purification 2012 Apr; 82(2):317.
Application：WB, Bacteria, Bacterial cells.
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Adeno-associated virus serotype 8 (AAV8) Gene Transfer Rescues a Neonatal Lethal Murine Model of Propionic Acidemia.
Chandler RJ, Chandrasekaran S, Carrillo-Carrasco N, Senac JS, Hofherr S, Barry MA, Venditti CP.
Human Gene Therapy 2011 Apr; 22(4):477.
Application：WB, Mouse, Liver.
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Ataxin-2 (Atxn2)-Knock-Out Mice Show Branched Chain Amino Acids and Fatty Acids Pathway Alterations.
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